RAF Typhoon fighter aircraft have operated alongside French aircraft in a joint strike on an hidden munitions depot in Syria used by the Daesh militant organization, according to the UK's MoD.
The location, identified by surveillance, was believed to be housing weapons and explosive materials, the statement said, and was positioned in mountainous terrain just north of Palmyra in the heart of Syria.
"Our fighter planes employed Paveway IV guided bombs to strike a number of access tunnels leading to the site... preliminary assessments suggest the objective was successfully hit," the MoD said.
There was no indication of any harm to civilians in the attack late on Saturday and every plane involved returned safely, the defence officials confirmed.
The Typhoon fighters were supported by a Voyager tanker plane.
IS - alternatively referred to as Daesh - established extremist governance over parts of both Syria and Iraq before its territorial defeat in 2019.
"This strike shows our UK leadership, and resolve to work closely with allied nations, to eliminate any revival of the terrorist group and their harmful and extremist ideologies in the region," Britain's Defence Chief the Defence Secretary said.
British military aircraft have carried out surveillance missions over Syria to "prevent any attempted comeback" of Islamic State subsequent to its routing at the battle of Baghuz in 2019, the ministry said.
"I must thank the personnel of our armed forces involved in this strike for their expertise and their courage," he said. "They were among thousands of British personnel stationed over Christmas and New Year. This action, to take out dangerous terrorists who pose a risk to our way of life, shows how British military are ready to step up, continuously, ensuring Britain's security within its borders and influential overseas."
During December, the American forces executed what it called a "large-scale strike" targeting Islamic State objectives in the country, subsequent to an ambush killed two US servicemembers and a civilian linguist in the Palmyra area.
The U.N. reports Islamic State still has between 5,000 and 7,000 combatants in both countries.